1.
Front Endocrinol (Lausanne)
; 14: 1183278, 2023.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37124730
RESUMO
From the time of its discovery and isolation in the mammalian hypothalamus, the decapeptide, gonadotropin-releasing hormone (GnRH), has also been found to be expressed in non-hypothalamic tissues and can elicit a diverse array of functions both in the brain and periphery. In cancer, past studies have targeted the gonadotropin-releasing hormone receptors (GnRHR) as a way to treat reproductive cancers due to its anti-tumorigenic effects. On the contrary, its metabolite, GnRH-(1-5), behaves divergently from its parental peptide through putative orphan G-protein coupled receptor (oGPCR), GPR101. In this review, we will focus on the potential roles of GnRH-(1-5) in the periphery with an emphasis on its effects on endometrial cancer progression.
Assuntos
Neoplasias do Endométrio , Hormônio Liberador de Gonadotropina , Feminino , Humanos , Hormônio Liberador de Gonadotropina/metabolismo , Fragmentos de Peptídeos/metabolismo , Receptores LHRH/metabolismo
2.
Mil Med
; 188(5-6): 123-124, 2023 05 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36632792